External pressure given on a mixed nerve causes loss of touch sensation while pain sensation remains relatively intact. On the other hand application of local anaesthetics on the same nerve, induces loss of pain sensation keeping touch sensation least affected. These observations can be explained by the following statements: A. External pressure causes loss of conduction of impulses in small diameter sensory nerve fibres B. Local anaesthetics depress the conduction of impulses in large diameter sensory nerve fibres
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