Sickle cell allele affects oxygen delivery to tissues and affects ones susceptibility to malaria. This is a pleotropic allele (affects more than one phenotypic traits). Under low CO availability, heterozygous individuals for this trait would face life 2 threatening sickle cell "Crises". Such individual remain less susceptible to malaria. Pleiotropic gene explain the reason why?

Sickle cell allele affects oxygen delivery to tissues and affects ones susceptibility to malaria. This is a pleotropic allele (affects more than one phenotypic traits). Under low CO availability, heterozygous individuals for this trait would face life 2 threatening sickle cell "Crises". Such individual remain less susceptible to malaria. Pleiotropic gene explain the reason why?

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M.Sc. Entrance

CSIR NET

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