A person suffering from thyrotoxicosis has extremely high level of thyroid hormone in blood. There is a failure of feed back regulation In hypothalamic-pitultary-thyrold axis. The detailed blood investigation exhibited high level of the following: 

A person suffering from thyrotoxicosis has extremely high level of thyroid hormone in blood. There is a failure of feed back regulation In hypothalamic-pitultary-thyrold axis. The detailed blood investigation exhibited high level of the following:
P. Thyroid stimulating hormone (TAT). Q. Thyroid stimulating immunoglobulin (TSI). R. Thyrotropin releasing hormone (TRH). S. Parathyroid hormone (PTA).
In your opinion, which one of the following is the reason for such thyrotoxicosis ?

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